Zebra and quagga mussels continue to spread across North America, creating significant operational, maintenance, and reliability challenges for dam owners and raw water users. Mussel infestation can block water conveyance systems, restrict flow, and increase safety risks to critical infrastructure. After mussels were first detected in Manitoba in 2013, Manitoba Hydro assessed the risks posed to its hydroelectric facilities and engaged specialized engineering and mussel management expertise to develop a mitigation strategy. Engineering and environmental evaluations were completed to review available treatment methodologies and design a program tailored to site-specific constraints, vulnerabilities and operational needs. An integrated approach was selected, combining automated short-term chlorination treatments with a comprehensive mussel monitoring program to track infestation and settlement trends and to inform on treatment implementation. Chlorination was chosen due to its proven effectiveness, operational flexibility, affordability, and ability to be fully neutralized before discharge. The monitoring program was implemented in 2021, followed by automated chlorination treatments at five hydroelectric stations to protect internal piping and once-through water supply systems. The program achieved complete mussel mortality at all monitored locations while maintaining environmental regulatory compliance. Ongoing monitoring and treatment continue to support reliable hydropower generation and reduced operational risk, providing a practical model for other dam owners facing similar invasive species challenges.